Human skin models: From healthy to disease-mimetic systems; characteristics and applications

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Moniz, T (Author) Other; Costa Lima, SCA (Author) Other; Salette Reis (Author) FFUP

Journal

Title: British Journal of Pharmacology

Vol. 177

Pages: 4314-4329

ISSN: 0007-1188

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00S-MYK

DOI: 10.1111/bph.15184

Abstract (EN): Skin drug delivery is an emerging route in drug development, leading to an urgent need to understand the behaviour of active pharmaceutical ingredients within the skin. Given, As one of the body's first natural defences, the barrier properties of skin provide an obstacle to the successful outcome of any skin drug therapy. To elucidate the mechanisms underlying this barrier, reductionist strategies have designed several models with different levels of complexity, using non-biological and biological components. Besides the detail of information and resemblance to human skin in vivo, offered by each in vitro model, the technical and economic efforts involved must also be considered when selecting the most suitable model. This review provides an outline of the commonly used skin models, including healthy and diseased conditions, in-house developed and commercialized models, their advantages and limitations, and an overview of the new trends in skin-engineered models.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16