Mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines

• Type: Chapter or Part of a Book
• Date: 2022

Authors

Barbosa, DJ (Author) Other; Felix Carvalho (Author) FFUP; Helena Carmo (Author) FFUP

Book

Title: Mitochondrial Intoxication

Pages: 271-297

ISBN: 9780323884624

Electronic ISBN: 9780323884631

Publisher: Elsevier

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-5GW

DOI: 10.1016/b978-0-323-88462-4.00014-6

Abstract (EN): Amphetamines represent a class of widely abused psychotropic drugs. Methamphetamine, amphetamine, and 3,4-methylenedioxymethamphetamine (¿ecstasy¿) represent well-recognized examples, but the use of natural, amphetamine-like compounds, including cathinone derivates, has been part of the human history for thousands of years. A variety of acute and long-term adverse effects have been disclosed in drug abusers, including neurotoxicity, in which a major role for mitochondria dysfunction has been depicted. At this level, perturbations in enzymes of tricarboxylic acid cycle, inhibition of electron transport chain components, and oxidative modifications in mitochondrial macromolecules represent well reported mechanisms underlying the neurotoxicity of these drugs. In this chapter, the toxic effects of amphetamines at the mitochondrial level are reviewed. © 2023 Elsevier Inc. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 26