Recent advances in the synthesis of xanthones and azaxanthones

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Resende, DISP (Author) Other; Duraes, F (Author) Other; Maia, M (Author) Other; Emilia Sousa (Author) FFUP; Pinto, MMM (Author) Other

Journal

Title: Organic Chemistry Frontiers

Vol. 7

Pages: 3027-3066

ISSN: 2052-4110

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00S-V2Y

DOI: 10.1039/d0qo00659a

Abstract (EN): Xanthones are importantO-heteroaromatic tricyclic molecules exhibiting a wide range of bioactivities and can represent a showcase to highlight the recent techniques and strategies in organic synthesis towards lead discovery and optimization. This review gives an insight into the recent literature disclosed to obtain the xanthone core, including the drug-like azaxanthones, isosteres of xanthones, by exploiting the optimization of well-known procedures as well as disruptive developed methodologies. With this review, it is expected to provide a useful chemical toolbox to synthetic medicinal chemistry focusing on these privileged structures, covering from 2012 to 2020, with some older examples of azaxanthones.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 40