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Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

Title
Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections
Type
Article in International Scientific Journal
Year
2022
Authors
Oliveira, D
(Author)
Other
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Anabela Borges
(Author)
FEUP
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Saavedra, MJ
(Author)
Other
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Fernanda Borges
(Author)
FCUP
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Simoes, M
(Author)
Other
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Simões M
(Author)
FEUP
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Journal
Title: Antibiotics Imported from Authenticus Search for Journal Publications
Vol. 11
Final page: 620
Publisher: MDPI
Other information
Authenticus ID: P-00W-FMX
Abstract (EN): Diabetic foot ulcers (DFUs) are a common result of a complex secondary complication of diabetes mellitus. More than half of DFUs become infected due to frequent colonization with Staphylococcus aureus. The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. In this study, 13 different phytochemicals-namely chalcone, juglone, cinnamic acid, trigonelline, Furvina-and four nitrovinylfuran derivatives-guaiazulene, alpha-bisabolol, farnesol and nerolidol-were selected to be tested as antibiotic enhancers. After minimum inhibitory and bactericidal concentration (MIC and MBC) determination of each molecule against different strains of S. aureus, including clinical isolates from diabetic foot wounds (CECT 976, Xu212, SA 1199B, RN4220, MJMC102, MJMC109, MJMC110 and MJMC111), their potentiation effects on the antibiotics fusidic acid, mupirocin, gentamicin, oxacillin and methicillin were evaluated through the disc diffusion method. Farnesol at sub-MIC was able to restore the activity of methicillin and oxacillin on the MJMC102 and MJMC111 strains, as well as two MRSA clinical isolates, and potentiated the effect of the remaining antibiotics. The results obtained demonstrate the great potential for the topical application of phytochemicals and derivatives as antibiotic resistance modifier agents to combat multidrug resistance in bacterial wound infections.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 17
Documents
File name Description Size
antibiotics-11-00620 (1) 3828.10 KB
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