Advances on Bacterial and Fungal Biofilms for the Production of Added-Value Compounds

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Carvalho, FM (Author) Other; Azevedo, A (Author) Other; Ferreira, MM (Author) Other; Filipe Mergulhão (Author) FEUP; Luciana Gomes (Author) FEUP

Journal

Title: BIOLOGY-BASEL

Vol. 11

Final page: 1126

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Associated Projects

ALiCE - ALiCE - Laboratório Associado em Engenharia Química

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

FilmProt - Utilização de biofilmes de Escherichia coli para a produção de proteínas recombinantes e outros compostos de elevado valor acrescentado

Other information

Authenticus ID: P-00W-Y2R

DOI: 10.3390/biology11081126

Abstract (EN): Simple Summary The production of bio-based materials, including organic acids, antibiotics, enzymes, ethanol, and hydrogen, is generally done by the cultivation of suspended cells rather than using immobilized cells. However, several studies suggest the application of productive biofilms as a reliable alternative for biocatalysis, with many advantages over suspended-growth systems. This review gives an overview of the breakthrough in the application of biofilm platforms for the sustainable production of valuable compounds, with particular insight into the latest advances in the production of recombinant proteins. Productive biofilms are shown to improve production rates and product yields, demonstrating great potential for industrial applications. In recent years, abundant research has been performed on biofilms for the production of compounds with biotechnological and industrial relevance. The use of biofilm platforms has been seen as a compelling approach to producing fine and bulk chemicals such as organic acids, alcohols, and solvents. However, the production of recombinant proteins using this system is still scarce. Biofilm reactors are known to have higher biomass density, operational stability, and potential for long-term operation than suspended cell reactors. In addition, there is an increasing demand to harness industrial and agricultural wastes and biorefinery residues to improve process sustainability and reduce production costs. The synthesis of recombinant proteins and other high-value compounds is mainly achieved using suspended cultures of bacteria, yeasts, and fungi. This review discusses the use of biofilm reactors for the production of recombinant proteins and other added-value compounds using bacteria and fungi.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 30