Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and cardiometabolic parameters and agreement for pre-diabetes diagnosis in patients with morbid obesity

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Guerreiro, V (Author) FMUP; Maia, I (Author) Other; Neves, JS (Author) FMUP; Salazar, D (Author) Other; Ferreira, MJ (Author) Other; Mendonca, F (Author) Other; Silva, MM (Author) Other; Borges Canha, M (Author) FMUP; Viana, S (Author) Other; Costa, C (Author) Other; Pedro, J (Author) Other; Varela, A (Author) Other; Lau, E (Author) FCNAUP; Freitas, P (Author) FMUP; Carvalho, Davide (Author) FMUP

Journal

Title: Diabetology and Metabolic Syndrome

Vol. 14

ISSN: 1758-5996

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00W-TX7

DOI: 10.1186/s13098-022-00865-2

Abstract (EN): Background One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with cardiometabolic risk markers and the level of agreement for prediabetes mellitus diagnosis, in a sample of patients with morbid obesity. Methods We retrospectively evaluated 656 patients with morbid obesity without diagnosed diabetes. To define prediabetes with 2hPG, 2022 American Diabetes Association guidelines criteria were used, while for 1hPG, glucose >= 155 mg/dL was considered. Cohen's Kappa coefficient was used to assess the agreement between both measures of prediabetes mellitus diagnosis. Results A Cohen's Kappa coefficient of 0.405 (p < 0.001) was obtained. The 1hPG were positively correlated with homeostatic model assessment for insulin resistance (HOMA-IR) (rho = 0.281, p < 0.001), fasting plasma glucose (FPG) (rho = 0.581, p < 0.001), glycated haemoglobin (Hb1AC) (rho = 0.347, p < 0.001) and were negatively correlated with homeostatic model assessment for cell-beta function (HOMA-beta) (rho = -0.092, p = 0.018). 2hPG were also correlated with the same parameters, except for HOMA-beta. Conclusion A fair agreement between 1 and 2hPG was verified. 1hPG criteria may be a useful indicator of beta-cell dysfunction and insulin resistance in patients with morbid obesity without diabetes diagnosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7