Total Luminal Volume Predicts Risk after Endovascular Aneurysm Repair

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Oliveira Pinto, J (Author) FMUP; Ferreira, RS (Author) Other; Oliveira, NFG (Author) Other; Hoeks, S (Author) Other; Van Rijn, MJ (Author) Other; Raa, ST (Author) Other; Mansilha A. (Author) FMUP; Verhagen, HJM (Author) Other; Goncalves, FB (Author) Other

Journal

Title: European Journal of Vascular and Endovascular Surgery

Vol. 59

Pages: 918-927

ISSN: 1078-5884

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00R-WRZ

DOI: 10.1016/j.ejvs.2020.02.011

Abstract (EN): Objective: Large aneurysm diameter represents a well known predictor of late complications after endovascular aneurysm repair (EVAR). However, the role of the thrombus free lumen inside the abdominal aortic aneurysm (AAA) sac is not clear. It was hypothesised that greater luminal volume represents a relevant risk factor for late complications after EVAR. Methods: A retrospective cohort analysis was performed including all patients undergoing EVAR from 2005 to 2016 at a tertiary referral institution. Pre-operative AAA lumen volume was measured in centre lumen line reconstructions and patients were stratified into quartiles according to luminal volume. The primary endpoint was freedom from AAA related complications. Secondary endpoints were freedom from neck events (type 1A endoleak, migration >5 mm or any pre-emptive neck related intervention), iliac related events (type 18 endoleak or pre-emptive iliac related intervention), and overall survival. Results: Four hundred and four patients were included: 101 in the first quartile (Q1; <61 cm(3)). Patients with higher luminal volumes had wider, shorter, and more angulated proximal necks. There were more ruptured AAA5, more aorto-uni-iliac implanted devices and patients outside neck instructions for use in the 4th quartile. Five year freedom from AAA related complications was 79%, 66%, 58% and 56%, respectively (p = .007). At five years, freedom from neck related events was 86%, 84%, 73%, and 71%, respectively, for the four groups (p = .009), and freedom from iliac related events was 96%, 91%, 88%, and 88%, respectively (p = .335). On multivariable analysis, luminal volume was an independent predictor of late complications (Q4 vs. Q1 - hazard ratio: 1.91, 95% confidence interval 1.01-3.6, p = .046). Overall survival at five years was not affected by lumen volume (p = .75). Conclusion: AAA luminal volume represents an important risk factor for AAA related complications. This information may be considered when deciding tailoring surveillance protocols after EVAR. However, larger studies are needed to validate this hypothesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10