Mitotic spindle multipolarity without centrosome amplification

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Helder Maiato (Author) FMUP; Logarinho, E (Author) Other

Journal

Title: Nature Cell Biology

Vol. 16

Pages: 386-U23

ISSN: 1465-7392

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 101 Citations

Scopus - 98 Citations

Other information

Authenticus ID: P-009-D4A

DOI: 10.1038/ncb2958

Abstract (EN): Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell division. Multipolar spindles are often seen in human cancers and are usually associated with supernumerary centrosomes that result from centrosome overduplication or cytokinesis failure. A less-understood path to multipolar spindle formation may arise due to loss of spindle pole integrity in response to spindle and/or chromosomal forces. Here we discuss the different routes leading to multipolar spindle formation, focusing on spindle multipolarity without centrosome amplification. We also present the distinct and common features between these pathways and discuss their therapeutic implications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12