Hyperlipidaemia and cardioprotection: Animal models for translational studies

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Andreadou, I (Author) Other; Schulz, R (Author) Other; Badimon, L (Author) Other; Adameova, A (Author) Other; Kleinbongard, P (Author) Other; Lecour, S (Author) Other; Nikolaou, PE (Author) Other; Falcao Pires, I (Author) FMUP; Vilahur, G (Author) Other; Woudberg, N (Author) Other; Heusch, G (Author) Other; Ferdinandy, P (Author) Other

Journal

Title: British Journal of Pharmacology

ISSN: 0007-1188

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 35 Citations

Other information

Authenticus ID: P-00R-P1W

DOI: 10.1111/bph.14931

Abstract (EN): Hyperlipidaemia is a well-established risk factor for cardiovascular diseases and therefore, many animal model have been developed to mimic the human abnormal elevation of blood lipid levels. In parallel, extensive research for the alleviation of ischaemia/reperfusion injury has revealed that hyperlipidaemia is a major co-morbidity that attenuates the cardioprotective effect of conditioning strategies (preconditioning, postconditioning and remote conditioning) and that of pharmacological interventions by interfering with cardioprotective signalling pathways. In the present review article, we summarize the existing data on animal models of hypercholesterolaemia (total, low density and HDL abnormalities) and hypertriglyceridaemia used in ischaemia/reperfusion injury and protection from it. We also provide recommendations on preclinical animal models to be used for translations of the cardioprotective strategies into clinical practice.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 25