Quinoxaline-1,4-dioxide derivatives inhibitory action in melanoma and brain tumor cells

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Silva, L (Author) Other; Coelho, P (Author) Other; soares, r (Author) FMUP; Prudencio, C (Author) Other; Vieira, M (Author) Other

Journal

Title: Future Medicinal Chemistry

Vol. 11

Pages: 645-658

ISSN: 1756-8919

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00Q-M87

DOI: 10.4155/fmc-2018-0251

Abstract (EN): Aim: Quinoxaline-1,4-dioxide derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. In this study, we investigated the bioactivity of five quinoxaline-1,4-di-N-oxides derivatives in different animal cell lines. Materials & methods: Using in vitro cell cultures, we evaluated the influence of quinoxaline-1,4-dioxide, 2-methylquinoxaline-1,4-dioxide, 2-amino-3-cyanoquinoxaline-1,4-dioxide, 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide and 2-hydroxyphenazine-N,N-dioxide (2HF) in the viability, migration and proliferation of nonmalignant (3T3-L1 and human dermal microvascular endothelial cell) and malignant (B16-F10, MeWo, GL-261 and BC3H1) cell lines. Results: The viability IC50 concentrations for each quinoxaline-1,4-di-N-oxide derivative were calculated, and a concomitant reduction of migration and proliferation was observed mainly in malignant cell lines. Conclusion: 2HF exhibited potent anti-viability, anti-migration and anti-proliferative actions selectively in tumor cells, nevertheless more studies are required to further investigate 2HF promising biologic effects. [GRAPHICS] .

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14