Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Longatto Filho, A (Author) Other; Pinheiro, C (Author) Other; Miranda Pereira, SMM (Author) Other; Etlinger, D (Author) Other; Moreira, MAR (Author) Other; Jube, LF (Author) Other; Queiroz, GS (Author) Other; Baltazar, F (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Gynecologic Oncology

Vol. 107

Pages: 45-51

ISSN: 0090-8258

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 39 Citations

Scopus - 43 Citations

Other information

Authenticus ID: P-004-74B

DOI: 10.1016/j.ygyno.2007.05.029

Abstract (EN): Objective. We sought to determine the significance of lymphatic vessel density (LVD) in pre-malignant lesions and carcinomas of the uterine cervix and to evaluate the prognostic value of lymphatic invasion and D2-40 positivity in tumor cells in the three histological types of invasive lesions. The correlation of LVD, lymphatic invasion and D2-40 positivity in tumor cells with EGER and COX-2 expressions was also evaluated. Methods. We studied 50 cervicitis, 50 low-grade squamous intraepithelial lesions (LSIL) (CIN1), 51 high-grade squamous intraepithelial lesions (HSIL) (CIN2/CTN3), 49 invasive squamous cells carcinomas (SCC), 43 adenocarcinomas (AC) and 30 adenosquamous cells carcinomas (ASC). The immunoreaction assay was performed using the monoclonal antibody D2-40. Results. Significant differences in LVD were found among all categories of pre-invasive and invasive lesions (P=0.001 and p<0.001, respectively). LVD in invasive lesions was significantly greater than in pre-invasive lesions (p<0.001) and no significant association was found between LVD in invasive lesions and both lymph node invasion and/or metastasis. D2-40 positivity in tumor cells was associated with a better prognosis in ASC cases. EGFR and COX-2 expressions in invasive lesions were not associated with LVD; however, they correlated with both lymphatic invasion and D2-40 positivity in tumor cells. Conclusions. Lymphatic neovascularization begins early in intraepithelial lesions and continues to increase towards malignancy. Both lymphatic invasion and decrease in D2-40 expression in tumor cells appear to have a prognostic value.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7