Ozonation of cytostatic drugs in aqueous phase

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Garcia Costa, LA (Author) Other; Gouveia, IAT (Author) FEUP; Pereira, MFR (Author) Other; Silva, Adrian (Author) FEUP; Alves, A (Author) Other; Madeira, ML (Author) Other; Mónica Santos (Author) FEUP; Luis Madeira (Author) FEUP

Journal

Title: Science of the Total Environment

Vol. 795

ISSN: 0048-9697

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Associated Projects

Healthy Waters - Healthy Waters - Identification, Elimination, Social Awareness and Education of Water Chemical and Biological Micropollutants with Health and Environmental Implications

Other information

Authenticus ID: P-00V-5K9

DOI: 10.1016/j.scitotenv.2021.148855

Abstract (EN): As the number of cancer patients increases, so does the consumption of cytostatic drugs, which are commonly used in chemotherapy. These compounds are already ubiquitous in wastewater treatment plant (WWTP) effluents and natural water streams, revealing the urgent need for efficient technologies for their removal from the aqueous phase. This work presents the elimination of five cytostatics of concern, found in Portuguese WWTP effluents: bicalutamide (BICA), capecitabine (CAP), cyclophosphamide (CYC), ifosfamide (IFO) and mycophenolic acid (MPA), using non-catalytic ozonation. Experiments were performed starting from trace-level concentrations (1 mu M) for all cytostatics at neutral pH (pH: 7.3 +/- 0.1) and room temperature (23 +/- 1 degrees C), employing different ozone dosages. Under the studied conditions, CAP and MPA were quickly eliminated by direct ozonation, whereas BICA, CYC and IFO were more slowly degraded, as they undergo a breakdown via hydroxyl radicals generation (HO center dot) exclusively. Increasing the O-3 dosage from 1 to 3 mgO(3)/mgDOC, CAP, MPA and IFO were completely removed, and BICA and CYC were converted more than 90% after 180 min. The presence of both inorganic ions and organic matter in real water matrices (river water, WWTP secondary effluent) did not affect the removal of CAP and MPA. Nonetheless, there was an inefficient and very fast O-3 consumption that resulted in only around 30% elimination of BICA, CYC and IFO, even if the reaction time is extended.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9