Introduction to vimentin and novel approaches

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Daniel Pozza (Author) FMUP; De Mello, RA (Author) Other

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-009-3N9

Abstract (EN): Intermediate filaments (IFs) are among the main cytoskeleton components in most animal cells, being intermediate in diameter between microtubules and actin filaments. Vimentin is one of the large IFsof eukaryotic cell's cytoskeleton, being the major protein in mesenchymal cells and it is frequently used as a developmental marker of cells and tissues. It may be overexpressed in several cancers, such as lung, breast, head and neck cancer, and sarcomas. Furthermore, vimentin pathways may influence benign disease pathogenesis, such as reumathoid arthritis and Crohn's disease. Thus, this chapter will summarize an overview concerning vimentin's molecular mechanisms and novel approaches.

Language: English

Type (Professor's evaluation): Scientific