New halogenated phenylcoumarins as tyrosinase inhibitors

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Matos, MJ (Author) Other; Santana, L (Author) Other; Uriarte, E (Author) Other; Delogu, G (Author) Other; Corda, M (Author) Other; Fadda, MB (Author) Other; Era, B (Author) Other; Fais, A (Author) Other

Journal

Title: Bioorganic and Medicinal Chemistry Letters

Vol. 21

Pages: 3342-3345

ISSN: 0960-894X

Publisher: Elsevier

Indexing

Scopus - 47 Citations

Other information

Authenticus ID: P-00R-0MH

DOI: 10.1016/j.bmcl.2011.04.012

Abstract (EN): With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold. The synthesized compounds 5-12 were evaluated as mushroom tyrosinase inhibitors showing, two of them, lower IC 50 than the umbelliferone. Compound 12 (IC 50 = 215 ¿M) is the best tyrosinase inhibitor of this series.

Language: English

Type (Professor's evaluation): Scientific