The role of salivary peptides in dental caries

• Type: Article in International Scientific Journal
• Date: 2005

Authors

vitorino, r (Author) Other; lobo, mjc (Author) Other; duarte, jr (Author) FADEUP; ferrer-correia, aj (Author) Other; domingues, pm (Author) Other; amado, fml (Author) Other

Journal

Title: Biomedical Chromatography

Vol. 19 No. 2

Pages: 214-222

ISSN: 0269-3879

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 72 Citations

Pubmed / Medline

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-000-3XQ

DOI: 10.1002/bmc.438

Abstract (EN): Dental caries is a complex disease, characterized by demineralization of tooth structure. With a protective role, several salivary phosphopeptides appear to be involved in remineralization processes, delaying the loss of tooth structure. In this work we have correlated peptide saliva composition with dental caries susceptibility through the analysis of saliva and hydroxyapatite-adsorbed salivary peptides samples. Saliva samples were obtained from two groups, a caries-free and a caries-susceptible group, and were analysed using HPLC-MS and a sequential extraction with 6 M of guanidine followed by trifluoroacetate. Data analysis has allowed us to verify a strong correlation between large amounts phosphopeptides (PRP1/3, histatin 1 and statherin), and the absence of dental caries, which reinforces the importance of these peptides in the maintenance of tooth integrity. In addition, in the caries-susceptible group a high number of peptide fragments was observed, suggesting a high proteolytic activity. Copyright (c) 2004 John Wiley D Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9