Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management

• Type: Article in International Scientific Journal
• Date: 2020-07-06

Authors

Jorge P. M. de Carvalho (Author) FCUP; Mariana P. Monteiro (Author) ICBAS; Carolina B. Lobato (Author) Other; Sofia S. Pereira (Author) Other; Marta Guimarães (Author) ICBAS; Tiago Morais (Author) Other; Pedro Oliveira (Author) ICBAS; Mário Nora (Author) Other

Journal

Title: Scientific Reports

Vol. 10

ISSN: 2045-2322

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00S-D6S

DOI: 10.1038/s41598-020-68029-8

Abstract (EN): Our aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N=13) with suspected PBH underwent a food and symptoms diary (FSD) record along with FGM over 14 days. Targeted data analysis confirmed the occurrence of low glucose events in parallel to meal-triggered symptoms. Glycaemic variability, as assessed by Mean Absolute Glucose change (MAG change), was increased, while a higher risk of glycaemic excursions towards both hyper and hypoglycaemia (ADRR(FGM)GT) was observed in those with more frequent and severe hypoglycaemia. The herein described hypoglycaemia risk index (LBGI(FGM)GT) with a cut-off value of 4.6 showed to have 100% sensitivity and 100% specificity for PBH. This pilot proof-of-concept study highlighted that FSD coupled with FGM followed by targeted data analysis, provides relevant insights towards PBH diagnosis and grading in a user-friendly and easy to implement study protocol. Furthermore, LBGI(FGM)GT demonstrated to be an excellent index for PBH diagnosis. The unexpected improvement of glucose profile noticed along the monitoring time also unravels a possible application for PBH management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12