A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Marano, RBM (Author) Other; Fernandes, T (Author) Other; Manaia, CM (Author) Other; Olga C Nunes (Author) FEUP; Morrison, D (Author) Other; Berendonk, TU (Author) Other; Kreuzinger, N (Author) Other; Telson, T (Author) Other; Corno, G (Author) Other; Fatta Kassinos, D (Author) Other; Merlin, C (Author) Other; Topp, E (Author) Other; Jurkevitch, E (Author) Other; Henn, L (Author) Other; Scott, A (Author) Other; Hess, S (Author) Other; Slipko, K (Author) Other; Laht, M (Author) Other; Kisand, V (Author) Other; Di Cesare, A (Author) Other; Karaolia, P (Author) Other; Michael, SG (Author) Other; Petre, AL (Author) Other; Rosal, R (Author) Other; Pruden, A (Author) Other; Riquelme, V (Author) Other; Aguera, A (Author) Other; Esteban, B (Author) Other; Luczkiewicz, A (Author) Other; Kalinowska, A (Author) Other; Leonard, A (Author) Other; Gaze, WH (Author) Other; Adegoke, AA (Author) Other; Stenstrom, TA (Author) Other; Pollice, A (Author) Other; Salerno, C (Author) Other; Schwermer, CU (Author) Other; Krzeminski, P (Author) Other; Guilloteau, H (Author) Other; Donner, E (Author) Other; Drigo, B (Author) Other; Libralato, G (Author) Other; Guida, M (Author) Other; Burgmann, H (Author) Other; Beck, K (Author) Other; Garelick, H (Author) Other; Tacaeo, M (Author) Other; Henriques, I (Author) Other; Martinez Alcala, I (Author) Other; Guillen Navarro, JM (Author) Other; Popowska, M (Author) Other; Piotrowska, M (Author) Other; Quintela Baluja, M (Author) Other; Bunce, JT (Author) Other; Polo Lopez, MI (Author) Other; Nahim Granados, S (Author) Other; Pons, MN (Author) Other; Milakovic, M (Author) Other; Udikovic Kolic, N (Author) Other; Ory, J (Author) Other; Ousmane, T (Author) Other; Caballero, P (Author) Other; Oliver, A (Author) Other; Rodriguez Mozaz, S (Author) Other; Balcazar, JL (Author) Other; Jaeger, T (Author) Other; Schwartz, T (Author) Other; Yang, Y (Author) Other; Zou, SC (Author) Other; Lee, YH (Author) Other; Yoon, Y (Author) Other; Herzog, B (Author) Other; Mayrhofer, H (Author) Other; Prakash, O (Author) Other; Nimonkar, Y (Author) Other; Heath, E (Author) Other; Baraniak, A (Author) Other; Abreu Silva, J (Author) Other; Choudhury, M (Author) Other; Munoz, LP (Author) Other; Krizanovic, S (Author) Other; Brunetti, G (Author) Other; Maile Moskowitz, A (Author) Other; Brown, C (Author) Other; Cytryn, E (Author) Other

Journal

Title: Environment International

Vol. 144

ISSN: 0160-4120

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00S-MJ9

DOI: 10.1016/j.envint.2020.106035

Abstract (EN): The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum beta-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (< 0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 10(3) colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11