Genetic effects on gene expression across human tissues

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Leinweber, WF (Author) Other; Lonsdale, JT (Author) Other; McDonald, A (Author) Other; Mestichelli, B (Author) Other; Myer, K (Author) Other; Roe, B (Author) Other; Salvatore, M (Author) Other; Shad, S (Author) Other; Thomas, JA (Author) Other; Walters, G (Author) Other; Washington, M (Author) Other; Wheeler, J (Author) Other; Bridge, J (Author) Other; Foster, BA (Author) Other; Gillard, BM (Author) Other; Karasik, E (Author) Other; Kumar, R (Author) Other; Miklos, M (Author) Other; Moser, MT (Author) Other; Jewell, SD (Author) Other; Montroy, RG (Author) Other; Rohrer, DC (Author) Other; Valley, D (Author) Other; Mash, DC (Author) Other; Davis, DA (Author) Other; Sobin, L (Author) Other; Barcus, ME (Author) Other; Branton, PA (Author) Other; Grp, EMW (Author) Other; Abell, NS (Author) Other; Balliu, B (Author) Other; Delaneau, O (Author) Other; Fresard, L (Author) Other; Gamazon, ER (Author) Other; Garrido Martin, D (Author) Other; Gewirtz, ADH (Author) Other; Gliner, G (Author) Other; Gloudemans, MJ (Author) Other; Han, B (Author) Other; He, AZ (Author) Other; Hormozdiari, F (Author) Other; Li, X (Author) Other; Liu, B (Author) Other; Kang, EY (Author) Other; McDowell, IC (Author) Other; Ongen, H (Author) Other; Palowitch, JJ (Author) Other; Peterson, CB (Author) Other; Quon, G (Author) Other; Ripke, S (Author) Other; Saha, A (Author) Other; Shabalin, AA (Author) Other; Shimko, TC (Author) Other; Sul, JH (Author) Other; Teran, NA (Author) Other; Tsang, EK (Author) Other; Zhang, H (Author) Other; Zhou, YH (Author) Other; Bustamante, CD (Author) Other; Cox, NJ (Author) Other; Guigo, R (Author) Other; Kellis, M (Author) Other; McCarthy, MI (Author) Other; Conrad, DF (Author) Other; Eskin, E (Author) Other; Li, G (Author) Other; Nobel, AB (Author) Other; Sabatti, C (Author) Other; Stranger, BE (Author) Other; Wen, X (Author) Other; Wright, FA (Author) Other; Ardlie, KG (Author) Other; Dermitzakis, ET (Author) Other; Lappalainen, T (Author) Other; Battle, A (Author) Other; Brown, CD (Author) Other; Engelhardt, BE (Author) Other; Montgomery, SB (Author) Other; Aguet, F (Author) Other; Ardlie, KG (Author) Other; Cummings, BB (Author) Other; Gelfand, ET (Author) Other; Getz, G (Author) Other; Hadley, K (Author) Other; Handsaker, RE (Author) Other; Huang, KH (Author) Other; Kashin, S (Author) Other; Karczewski, KJ (Author) Other; Lek, M (Author) Other; Li, X (Author) Other; MacArthur, DG (Author) Other; Nedzel, JL (Author) Other; Nguyen, DT (Author) Other; Noble, MS (Author) Other; Segre, AV (Author) Other; Trowbridge, CA (Author) Other; Tukiainen, T (Author) Other; Abell, NS (Author) Other; Balliu, B (Author) Other; Barshir, R (Author) Other; Basha, O (Author) Other; Battle, A (Author) Other; Bogu, GK (Author) Other; Brown, A (Author) Other; Brown, CD (Author) Other; Castel, SE (Author) Other; Chen, LS (Author) Other; Chiang, C (Author) Other; Conrad, DF (Author) Other; Cox, NJ (Author) Other; Damani, FN (Author) Other; Davis, JR (Author) Other; Delaneau, O (Author) Other; Dermitzakis, ET (Author) Other; Engelhardt, BE (Author) Other; Eskin, E (Author) Other; Ferreira, PG (Author) Other; Fresard, L (Author) Other; Gamazon, ER (Author) Other; Garrido Martin, D (Author) Other; Gewirtz, ADH (Author) Other; Gliner, G (Author) Other; Gloudemans, MJ (Author) Other; Guigo, R (Author) Other; Hall, IM (Author) Other; Han, B (Author) Other; He, Y (Author) Other; Hormozdiari, F (Author) Other; Howald, C (Author) Other; Im, HK (Author) Other; Jo, B (Author) Other; Kang, EY (Author) Other; Kim, Y (Author) Other; Kim Hellmuth, S (Author) Other; Lappalainen, T (Author) Other; Li, G (Author) Other; Li, X (Author) Other; Liu, B (Author) Other; Mangul, S (Author) Other; McCarthy, MI (Author) Other; McDowell, IC (Author) Other; Mohammadi, P (Author) Other; Monlong, J (Author) Other; Montgomery, SB (Author) Other; Munoz Aguirre, M (Author) Other; Ndungu, AW (Author) Other; Nicolae, DL (Author) Other; Nobel, AB (Author) Other; Oliva, M (Author) Other; Ongen, H (Author) Other; Palowitch, JJ (Author) Other; Panousis, N (Author) Other; Papasaikas, P (Author) Other; Park, Y (Author) Other; Parsana, P (Author) Other; Payne, AJ (Author) Other; Peterson, CB (Author) Other; Quan, J (Author) Other; Reverter, F (Author) Other; Sabatti, C (Author) Other; Saha, A (Author) Other; Sammeth, M (Author) Other; Scott, AJ (Author) Other; Shabalin, AA (Author) Other; Sodaei, R (Author) Other; Stephens, M (Author) Other; Stranger, BE (Author) Other; Strober, BJ (Author) Other; Sul, JH (Author) Other; Tsang, EK (Author) Other; Urbut, S (Author) Other; De Bunt, MV (Author) Other; Wang, G (Author) Other; Wen, X (Author) Other; Wright, FA (Author) Other; Xi, HS (Author) Other; Yeger Lotem, E (Author) Other; Zappala, Z (Author) Other; Zaugg, JB (Author) Other; Zhou, YH (Author) Other; Akey, JM (Author) Other; Bates, D (Author) Other; Chan, J (Author) Other; Chen, LS (Author) Other; Claussnitzer, M (Author) Other; Demanelis, K (Author) Other; Diegel, M (Author) Other; Doherty, JA (Author) Other; Feinberg, AP (Author) Other; Fernando, MS (Author) Other; Halow, J (Author) Other; Hansen, KD (Author) Other; Haugen, E (Author) Other; Hickey, PF (Author) Other; Hou, L (Author) Other; Jasmine, F (Author) Other; Jian, R (Author) Other; Jiang, L (Author) Other; Johnson, A (Author) Other; Kaul, R (Author) Other; Kellis, M (Author) Other; Kibriya, MG (Author) Other; Lee, K (Author) Other; Li, JB (Author) Other; Li, Q (Author) Other; Li, X (Author) Other; Lin, J (Author) Other; Lin, S (Author) Other; Linder, S (Author) Other; Linke, C (Author) Other; Liu, Y (Author) Other; Maurano, MT (Author) Other; Molinie, B (Author) Other; Montgomery, SB (Author) Other; Nelson, J (Author) Other; Neri, FJ (Author) Other; Oliva, M (Author) Other; Park, Y (Author) Other; Pierce, BL (Author) Other; Rinaldi, NJ (Author) Other; Rizzardi, LF (Author) Other; Sandstrom, R (Author) Other; Skol, A (Author) Other; Smith, KS (Author) Other; Snyder, MP (Author) Other; Stamatoyannopoulos, J (Author) Other; Stranger, BE (Author) Other; Tang, H (Author) Other; Tsang, EK (Author) Other; Wang, L (Author) Other; Wang, M (Author) Other; Van Wittenberghe, N (Author) Other; Wu, F (Author) Other; Zhang, R (Author) Other; Fund, NC (Author) Other; Nierras, CR (Author) Other; Nci, N (Author) Other; Branton, PA (Author) Other; Carithers, LJ (Author) Other; Guan, P (Author) Other; Moore, HM (Author) Other; Rao, A (Author) Other; Vaught, JB (Author) Other; Nhgri, N (Author) Other; Gould, SE (Author) Other; Lockart, NC (Author) Other; Martin, C (Author) Other; Struewing, JP (Author) Other; Volpi, S (Author) Other; Nimh, N (Author) Other; Addington, AM (Author) Other; Koester, SE (Author) Other; Nida, N (Author) Other; Little, AR (Author) Other; Brigham, LE (Author) Other; Hasz, R (Author) Other; Hunter, M (Author) Other; Johns, C (Author) Other; Johnson, M (Author) Other; Kopen, G (Author) Other; Leinweber, WF (Author) Other; Lonsdale, JT (Author) Other; McDonald, A (Author) Other; Mestichelli, B (Author) Other; Myer, K (Author) Other; Roe, B (Author) Other; Salvatore, M (Author) Other; Shad, S (Author) Other; Thomas, JA (Author) Other; Walters, G (Author) Other; Washington, M (Author) Other; Wheeler, J (Author) Other; Bridge, J (Author) Other; Foster, BA (Author) Other; Gillard, BM (Author) Other; Karasik, E (Author) Other; Kumar, R (Author) Other; Miklos, M (Author) Other; Moser, MT (Author) Other; Jewell, SD (Author) Other; Montroy, RG (Author) Other; Rohrer, DC (Author) Other; Valley, DR (Author) Other; Davis, DA (Author) Other; Mash, DC (Author) Other; Undale, AH (Author) Other; Smith, AM (Author) Other; Tabor, DE (Author) Other; Roche, NV (Author) Other; McLean, JA (Author) Other; Vatanian, N (Author) Other; Robinson, KL (Author) Other; Sobin, L (Author) Other; Barcus, ME (Author) Other; Valentino, KM (Author) Other; Qi, L (Author) Other; Hunter, S (Author) Other; Hariharan, P (Author) Other; Singh, S (Author) Other; Um, KS (Author) Other; Matose, T (Author) Other; Tomaszewski, MM (Author) Other; Study, E (Author) Other; Barker, LK (Author) Other; Mosavel, M (Author) Other; Siminoff, LA (Author) Other; Traino, HM (Author) Other; Flicek, P (Author) Other; Juettemann, T (Author) Other; Ruffier, M (Author) Other; Sheppard, D (Author) Other; Taylor, K (Author) Other; Trevanion, SJ (Author) Other; Zerbino, DR (Author) Other; Craft, B (Author) Other; Goldman, M (Author) Other; Haeussler, M (Author) Other; Kent, WJ (Author) Other; Lee, CM (Author) Other; Paten, B (Author) Other; Rosenbloom, KR (Author) Other; Vivian, J (Author) Other; Zhu, J (Author) Other; Aguet, F (Author) Other; Brown, AA (Author) Other; Castel, SE (Author) Other; Davis, JR (Author) Other; He, Y (Author) Other; Jo, B (Author) Other; Mohammadi, P (Author) Other; Park, Y (Author) Other; Parsana, P (Author) Other; Segre, AV (Author) Other; Strober, BJ (Author) Other; Zappala, Z (Author) Other; Cummings, BB (Author) Other; Gelfand, ET (Author) Other; Hadley, K (Author) Other; Huang, KH (Author) Other; Lek, M (Author) Other; Li, X (Author) Other; Nedzel, JL (Author) Other; Nguyen, DY (Author) Other; Noble, MS (Author) Other; Sullivan, TJ (Author) Other; Tukiainen, T (Author) Other; MacArthur, DG (Author) Other; Getz, G (Author) Other; Management, NP (Author) Other; Addington, A (Author) Other; Guan, P (Author) Other; Koester, S (Author) Other; Little, AR (Author) Other; Lockhart, NC (Author) Other; Moore, HM (Author) Other; Rao, A (Author) Other; Struewing, JP (Author) Other; Volpi, S (Author) Other; Collection, B (Author) Other; Brigham, LE (Author) Other; Hasz, R (Author) Other; Hunter, M (Author) Other; Johns, C (Author) Other; Johnson, M (Author) Other; Kopen, G (Author) Other

Journal

Title: Nature

Vol. 550

Pages: 204-+

ISSN: 0028-0836

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 1527 Citations

Scopus - 1540 Citations

Scientific classification

CORDIS: Natural sciences > Biological sciences > Biology > Computational biology ; Technological sciences > Engineering > Computer engineering

FOS: Natural sciences > Computer and information sciences ; Natural sciences > Biological sciences

Other information

Authenticus ID: P-00N-6G7

DOI: 10.1038/nature24277

Abstract (EN): Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 37