Landscape of transcription in human cells

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Djebali, S (Author) Other; Davis, CA (Author) Other; Merkel, A (Author) Other; Dobin, A (Author) Other; Lassmann, T (Author) Other; Mortazavi, A (Author) Other; Tanzer, A (Author) Other; Lagarde, J (Author) Other; Lin, W (Author) Other; Schlesinger, F (Author) Other; Xue, CH (Author) Other; Marinov, GK (Author) Other; Khatun, J (Author) Other; Williams, BA (Author) Other; Zaleski, C (Author) Other; Rozowsky, J (Author) Other; Roeder, M (Author) Other; Kokocinski, F (Author) Other; Abdelhamid, RF (Author) Other; Alioto, T (Author) Other; Antoshechkin, I (Author) Other; Baer, MT (Author) Other; Bar, NS (Author) Other; Batut, P (Author) Other; Bell, K (Author) Other; Bell, I (Author) Other; Chakrabortty, S (Author) Other; Chen, X (Author) Other; Chrast, J (Author) Other; Curado, J (Author) Other; Derrien, T (Author) Other; Drenkow, J (Author) Other; Dumais, E (Author) Other; Dumais, J (Author) Other; Duttagupta, R (Author) Other; Falconnet, E (Author) Other; Fastuca, M (Author) Other; Fejes Toth, K (Author) Other; Ferreira, P (Author) Other; Foissac, S (Author) Other; Fullwood, MJ (Author) Other; Gao, H (Author) Other; Gonzalez, D (Author) Other; Gordon, A (Author) Other; Gunawardena, H (Author) Other; Howald, C (Author) Other; Jha, S (Author) Other; Johnson, R (Author) Other; Kapranov, P (Author) Other; King, B (Author) Other; Kingswood, C (Author) Other; Luo, OJ (Author) Other; Park, E (Author) Other; Persaud, K (Author) Other; Preall, JB (Author) Other; Ribeca, P (Author) Other; Risk, B (Author) Other; Robyr, D (Author) Other; Sammeth, M (Author) Other; Schaffer, L (Author) Other; See, LH (Author) Other; Shahab, A (Author) Other; Skancke, J (Author) Other; Suzuki, AM (Author) Other; Takahashi, H (Author) Other; Tilgner, H (Author) Other; Trout, D (Author) Other; Walters, N (Author) Other; Wang, H (Author) Other; Wrobel, J (Author) Other; Yu, YB (Author) Other; Ruan, XA (Author) Other; Hayashizaki, Y (Author) Other; Harrow, J (Author) Other; Gerstein, M (Author) Other; Hubbard, T (Author) Other; Reymond, A (Author) Other; Antonarakis, SE (Author) Other; Hannon, G (Author) Other; Giddings, MC (Author) Other; Ruan, YJ (Author) Other; Wold, B (Author) Other; Carninci, P (Author) Other; Guigo, R (Author) Other; Gingeras, TR (Author) Other

Journal

Title: Nature

Vol. 489

Pages: 101-108

ISSN: 0028-0836

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3164 Citations

Scopus - 3268 Citations

Scientific classification

CORDIS: Natural sciences > Biological sciences > Biology > Computational biology ; Natural sciences > Biological sciences > Biology > Molecular biology

FOS: Natural sciences > Biological sciences ; Natural sciences > Computer and information sciences

Other information

Authenticus ID: P-009-GBV

DOI: 10.1038/nature11233

Abstract (EN): Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8