Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Silva, AT (Author) Other; Bento, CM (Author) Other; Pena, AC (Author) Other; Figueiredo, LM (Author) Other; Prudencio, C (Author) Other; Aguiar, L (Author) Other; Silva, T (Author) Other; Ferraz, R (Author) Other; Gomes, MS (Author) ICBAS; Catia Teixeira (Author) FCUP; Paula Gomes (Author) FCUP

Journal

Title: Molecules

Vol. 25

Final page: 66

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00R-HFH

DOI: 10.3390/molecules25010066

Abstract (EN): Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15