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Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

Title
Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid
Type
Article in International Scientific Journal
Year
2019
Authors
Chavarria, D
(Author)
Other
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Fernandes, C
(Author)
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Silva, T
(Author)
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Garrido, J
(Author)
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Fernando Remiao
(Author)
FFUP
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Oliveira, PJ
(Author)
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Fernanda Borges
(Author)
FCUP
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Journal
Vol. 17
Pages: 9646-9654
ISSN: 1477-0520
Other information
Authenticus ID: P-00R-C3R
Abstract (EN): We report the synthesis of 4-thioferulic acid (TFA), a new ferulic acid (FA) derivative, and highlight the differences between the two compounds concerning rate and mechanism of radical scavenging activity, redox potential, acidity of the phenol/thiophenol moieties, cytotoxicity in differentiated SH-SY5Y cells, and neuroprotection against hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BHP) in the same cellular model.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 9
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