Photostabilization strategies of photosensitive drugs

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Coelho, L (Author) Other; Almeida, IF (Author) FFUP; Sousa Lobo JM (Author) FFUP; Paulo Silva (Author) FFUP

Journal

Title: International Journal of Pharmaceutics

Vol. 541

Pages: 19-25

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 30 Citations

Other information

Authenticus ID: P-00N-MWP

DOI: 10.1016/j.ijpharm.2018.02.012

Abstract (EN): Purpose: Several active compounds are sensitive to light, especially to the ultraviolet radiation (UV-R) leading to their degradation or modification, with lost or decrease of their biological activity. The aim of this study was to perform a systematic review regarding photostabilization strategies used on health products and perform a critical appraisal of their effectiveness. Results: The bibliographic search identified 2261 results and merely 40 studies met the selection criteria. Of these, 85% referred to encapsulation strategies, 10% to antioxidants and 5% to the use of solar filters. Cyclodextrins (CD's) were the most used encapsulation systems (32.5%) followed by liposomes and lipid nanoparticles (each 17.5%), microparticles (15%) and polymeric nanoparticles (10%). The most effective were found to be liposomes and lipid nanoparticles. However, the different methodological conditions used limit the true relevance of this finding. Conclusions: A gold standard strategy suitable for all compounds cannot be proposed. Instead, case-by-case evaluation, supported on the photodegradation mechanism is recommended. Systematic studies that compare different photostabilization strategies undertaken with the same irradiation conditions are also needed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7