New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Diniz, C (Author) FFUP; Suliburska, J (Author) Other; Ferreira, Isabel (Author) FFUP

Journal

Title: Molecular Nutrition & Food Research

Vol. 61

Final page: 1600912

ISSN: 1613-4125

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 14 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00N-JVS

DOI: 10.1002/mnfr.201600912

Abstract (EN): Polyphenols can be found in natural products of plant origin, including vegetables, fruits, and beverages. A large number of these plant origin compounds are an integral part of the human diet and in the past decade evidence has shown their beneficial properties in human health, by acting in several cell signaling pathways. Among other beneficial effects, polyphenols have been associated with angiogenesis. Increasing evidence highlighting the ability of dietary polyphenols to influence angiogenesis by interfering with multiple signaling pathways is debated. Particular emphasis is given to the mechanisms that ultimately may induce the formation of capillary-like structures (by increasing endothelial cell proliferation, migration, and invasion) or, conversely, may inhibit the steps of angiogenesis leading to the inhibition/regress of vascular development. Dietary polyphenols can, therefore, be viewed as promising nutraceuticals but important aspects have still to be further investigated, to deep knowledge concerning their concentration-mediated effects, effect of specific polyphenols, and respective metabolites, to ensure their appropriate and effective usefulness as proangiogenic or antiangiogenic nutraceuticals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17