Targeted macrophages delivery of rifampicin-loaded lipid nanoparticles to improve tuberculosis treatment

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Vieira, ACC (Author) Other; Magalhaes, J (Author) Other; Rocha, S (Author) Other; Cardoso, MS (Author) Other; Santos, SG (Author) Other; Margarida Borges (Author) FFUP; Pinheiro, M (Author) Other; Salette Reis (Author) FFUP

Journal

Title: Nanomedicine

Vol. 12

Pages: 2721-2736

ISSN: 1743-5889

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-00N-8TA

DOI: 10.2217/nnm-2017-0248

Abstract (EN): Aim: This work aims to develop a mannosylated nanostructured lipid carrier (NLC) loaded with rifampicin to improve tuberculosis treatment. Materials & methods: An active targeting strategy was used and the nanoparticles were characterized. Effects on cell viability and the antimycobacterial activity of the nanoformulations were evaluated. Results: The nanoparticles developed exhibited a size of about 315 nm and polydispersity <0.2. The drug encapsulation efficiency was higher than 90% and its release was sensitive to pH. The mannosylated NLCs showed efficient uptake by bone marrow derived macrophages. Further, rifampicin-loaded mannosylated NLCs were more efficient in inducing a decrease of intracellular growth of mycobacteria. Conclusion: The NLCs developed can be used as a promising carrier for safer and efficient management of tuberculosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16