Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis (vol 2017, 3793817, 2017 )

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Matos, Liliana (Author) FMDUP; Gouveia, Alexandra (Author) FCNAUP; Almeida, H (Author) Other

Journal

Title: Oxidative Medicine and Cellular Longevity

No. ID 9172085

Pages: [1-10]

ISSN: 1942-0900

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00Q-YEQ

DOI: 10.1155/2017/9172085

Abstract (EN): Copper sulfate-induced premature senescence (CuSO4-SIPS) consistently mimics molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has been associated with age-related cell/tissue dysfunction and susceptibility to human disorders. Resveratrol is a polyphenolic compound with proven antiaging properties under certain conditions. In this setting, we aimed to evaluate the ability of resveratrol to attenuate cellular senescence induction and to unravel related molecularmechanisms. Resveratrol attenuated typical senescence-induced alterations to cell morphology, senescence- associated betagalactosidase activity, and cell proliferation in CuSO4-SIPS WI-38 fibroblasts. The mechanisms implicated in this antisenescence effect seem to be independent of the regulation of senescence-associated genes and proteins but are reliant on cellular proteostasis improvement. In fact, resveratrol supplementation restores copper-induced increases in protein content, attenuates immunoglobulin-binding protein levels, and reduces carbonylated and polyubiquitinated proteins by inducing autophagy. Our data provide compelling evidence for the beneficial effects of resveratrol by mitigating stressful consequences associated with CuSO4-SIPS via modulation of protein quality control systems. These findings highlight the importance of balanced cellular proteostasis and add further knowledge regarding molecular mechanisms mediating the antisenescence effects of resveratrol. Moreover, they contribute to the identification of specific molecular targets whose modulation may prevent age-associated cell dysfunction and improve human healthspan.

Language: English

Type (Professor's evaluation): Scientific

Notes: Erratum to ¿Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis¿ Liliana Matos, Alexandra Monteiro Gouveia, and Henrique Almeida Oxidative Medicine and Cellular Longevity Volume 2017 (2017), Article ID 3793817, 12 pages Published 9 February 2017

No. of pages: 10