Structure-activity relationship studies for multitarget antithrombotic drugs

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Neves, AR (Author) Other; Marta Correia da Silva (Author) FFUP; Emilia Sousa (Author) FFUP; Pinto, M (Author) Other

Journal

Title: Future Medicinal Chemistry

Vol. 8

Pages: 2305-2355

ISSN: 1756-8919

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00M-A4G

DOI: 10.4155/fmc-2015-0020

Abstract (EN): Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 51