Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Luisa L C Vale (Author) FCUP; Eduardo F Marques (Author) FCUP; Sandra G. Silva (Author) Other

Journal

Title: Chemistry - A European Journal

Vol. 21

Pages: 4092-4101

ISSN: 0947-6539

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Physical sciences > Chemistry > Organic chemistry ; Physical sciences > Chemistry > Physical chemistry

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-00A-913

DOI: 10.1002/chem.201406111

Subject: Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers

Abstract (EN): Vesicles based on mixed cationic and anionic surfactants (catanionic vesicles) offer a number of advantageous colloidal features over conventional lipid-based vesicles, namely spontaneity in formation, long-term stability, and easy modulation of size and charge. If biocompatibility is added through rational design of the chemical components, the potential for biorelated applications further emerges. Here, we report for the first time on two catanionic vesicle systems in which both ionic amphiphiles are derivatized from the same amino acid-serine-with the goal of enhancing aggregate biocompatibility. Phase behavior maps for a mixture with chain length symmetry, 12Ser/12-12Ser, and another with asymmetry, 16Ser/8-8Ser, are presented, for which regions of vesicles, micelles, and coexisting aggregates are identified. For the asymmetric mixture, detailed phase behavior and microstructure characterization have been carried out based on surface tension, light microscopy, cryo-SEM, cryo-TEM, and dynamic light scattering analysis. Vesicles are found with tunable mean size, pH, and zeta potential. Changes in aggregate shape with varying composition and the effect of preparation methods and aging on vesicle features and stability have been investigated in detail. The results are discussed in the light of self-assembly models and related catanionic systems reported before. A versatile system of robust vesicles is thus presented for potential applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10