Immune response dynamics

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Burroughs, NJ (Author) Other; Bruno M P M Oliveira (Author) FCNAUP; Alberto A. Pinto (Author) FCUP; Ferreira, M (Author) Other

Journal

Title: Mathematical and Computer Modelling

Vol. 53 No. 7/8

Pages: 1410-1419

ISSN: 0895-7177

Publisher: Pergamon Press - Elsevier

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-002-SGK

DOI: 10.1016/j.mcm.2010.02.040

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory T cells and T cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of T cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10