Nature meets nurture: molecular genetics of gastric cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Milne, AN (Author) Other; Carneiro F (Author) FMUP; O'Morain, C (Author) Other; Offerhaus, GJA (Author) Other

Journal

Title: Human Genetics

Vol. 126 No. 5

Pages: 615-628

ISSN: 0340-6717

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 168 Citations

Scopus - 184 Citations

Other information

Authenticus ID: P-003-ENB

DOI: 10.1007/s00439-009-0722-x

Abstract (EN): The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to look at the larger picture in terms of how to tackle the problem of solving this multi-piece puzzle. In this review, the environmental nurturing of intestinal cancer is discussed, beginning with epidemiology (known causative factors for inducing molecular change), an update of H. pylori research, including the role of inflammation and stem cells in premalignant lesions. The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14