Low-grade systemic inflammation and suboptimal bone mineral density throughout adolescence: a prospective study in girls

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Lucas, R (Author) FMUP; Ramos E (Author) FMUP; Oliveira A (Author) FMUP; Monjardino, T (Author) Other; Barros H (Author) FMUP

Journal

Title: Clinical Endocrinology

Vol. 77

Pages: 665-671

ISSN: 0300-0664

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-002-454

DOI: 10.1111/j.1365-2265.2012.04430.x

Abstract (EN): Objective We aimed at quantifying the associations between high-sensitivity C-reactive protein (hs-CRP) and forearm bone mineral density (BMD) throughout adolescence in overweight and normal-weight girls. Design Prospective cohort study. Patients 346 girls born in 1990 and attending schools in Porto, Portugal. Measurements Adolescents were evaluated at 13 and 17 similar to years of age using a standard protocol. Forearm BMD was measured by dual-energy X-ray absorptiometry. Anthropometric assessment included weight, height, body fat percentage and waist circumference. Girls were categorized according to age- and sex-specific body mass index (BMI) percentiles as normal weight in both evaluations or overweight in at least one assessment. Pubertal development was estimated using menarche age. Serum hs-CRP was determined using particle-enhanced immunonephelometry. Hs-CRP was log-transformed, and associations were quantified using linear regression coefficients and 95% confidence intervals (95%CI). Results An inverse association between hs-CRP and BMD was observed from 13 similar to years of age in overweight girls [-11.26 similar to mg/cm2 (-21.99, -0.52)]. Among normal-weight adolescents, 13-year-old hs-CRP was negatively associated with prospective BMD variation between 13 and 17 similar to years of age [-1.90 similar to mg/cm2 similar to year (-3.35, -0.45)]. Overweight girls who maintained higher levels of hs-CRP throughout adolescence had lower 17-year-old BMD (adjusted mean 0.441 vs 0.483 similar to g/cm2 in those who remained with lower levels of hs-CRP). At 17 similar to years of age, significant inverse associations were found between hs-CRP and BMD among normal-weight and overweight girls. Conclusions Obesity-related early systemic inflammation might be involved in suboptimal bone accrual, particularly in overweight girls.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7