Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites

• Type: Article in International Scientific Journal
• Date: 2016-05-08

Authors

Klara Slezakova (Author) FEUP; Marta Oliveira (Author) Other; Maria José Alves (Author) Other; Adília Fernandes (Author) Other; João Paulo Teixeira (Author) Other; Cristina Delerue Matos (Author) Other; Maria do Carmo Pereira (Author) FEUP; Simone Morais (Author) Other

Journal

Title: International Journal of Hygiene and Environmental Health

Vol. 219 No. 8

Pages: 857-866

ISSN: 1438-4639

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Pubmed / Medline

Scientific classification

CORDIS: Natural sciences > Environmental science

FOS: Medical and Health sciences > Health sciences

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00M-8JD

DOI: 10.1016/j.ijheh.2016.07.011

Abstract (EN): The concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (10HPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (Sigma OH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with Sigma OH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of Sigma OH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 10HPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 10HPy decreased. The detected urinary 10HPy concentrations (1.73 x 10(-2) to 0.152 mu mol/mol creatinine in exposed subjects versus 1.21 x 10(-2) to 5.44 x 10(-2) mu mol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5 mu mol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus. the inclusion of other metabolites, in addition to 10HPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and Sigma OH-PAHs corroborating the prevalence of an emission source.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10