Oxidative and Non-Oxidative Metabolomics of Ethanol

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Ricardo Jorge Dinis Oliveira (Author) FMUP

Journal

Title: Current Drug Metabolism

Vol. 17

Pages: 327-335

ISSN: 1389-2002

Publisher: Bentham

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-00K-B75

DOI: 10.2174/1389200217666160125113806

Abstract (EN): Background: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. Objective: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites. Method: An exhaustive literature search was carried out using textual and structural queries for ethanol and related known metabolizing enzymes and metabolites. Results: The main pathway of metabolism is catalyzed by cytosolic alcohol dehydrogenase, which exhibits multiple isoenzymes and genetic polymorphisms with clinical and forensic implications. Another two oxidative routes, the highly inducible CYP2E1 system and peroxisomal catalase may acquire relevance under specific circumstances. In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide, ethyl sulfate, ethyl phosphate, ethyl nitrite, phosphatidylethanol and fatty acid ethyl esters. These metabolites represent alternative biomarkers since they can be detected several hours or days after ethanol exposure. Conclusion: It is expected that knowing the metabolomics of ethanol may provide additional insights to better understand the toxicological effects and the variability of dose response.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9