Bilirubin is independently associated with oxidized LDL levels in young obese patients

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Henrique Nascimento (Author) Other; Ana Ines Alves (Author) Other; Susana Coimbra (Author) Other; Cristina Catarino (Author) FFUP; Diana Gomes (Author) Other; Bronze da Rocha, E (Author) FFUP; Elisio Costa (Author) FFUP; Petronila Rocha Pereira (Author) Other; Luisa Aires (Author) Other; J. Mota (Author) FADEUP; Helena Ferreira Mansilha (Author) Other; Carla Rego (Author) Other; Alice Santos Silva (Author) FFUP; Luis Belo (Author) FFUP

Journal

Title: Diabetology and Metabolic Syndrome

Vol. 7

Final page: 4

ISSN: 1758-5996

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-00A-6A3

DOI: 10.1186/1758-5996-7-4

Abstract (EN): Background: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. Findings: 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (beta = 0.665, P < 0.001), followed by TB (beta = -0.202, P = 0.002) and HOMAIR (beta = 0.163, P = 0.010). Conclusions: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5