Tissues Regeneration and Repair

Code:

EBE0185

Acronym:

RRTE

Keywords
Classification	Keyword
OFICIAL	Biomedical Engineering

Instance: 2010/2011 - 1S

Active?	Yes
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MEB	16	Syllabus	1	-	5	42	135
MIB	9	Syllabus	4	-	5	42	135
PRODEB	3	Syllabus	1	-	5	42	135

Teaching language

Suitable for English-speaking students

Objectives

Increased life expectancy is a result of recent developments in the treatment of diseases, in part, due to advances made in Biomaterials science and Tissue Engineering. Nevertheless, there are still no fully effective clinical solutions in place to repair and/or regenerate the majority of tissues and organs.
Regenerative Medicine approaches are based on the development and/or manipulation of molecules, cells, tissues or organs towards the repair, replacement or support of body parts that suffered a lesion. Regenerative medicine can be defined as the science of persuading the body to heal itself by providing, in suitable sites, the molecular signals, cells and structures. Basically, it involves the application of principles and methods of engineering and life sciences, aimed at the development of biological substitutes that can restore, maintain or ameliorate tissue function.
This course will present the main strategies currently under development or either in clinical trials or in the market, to promote tissue regeneration and restoration of function. A wide range of applications, from the regeneration of the skin, musculoskeletal system and cardiovascular system, as well as emerging areas such as the regeneration of the nervous system, will be addressed.

Program

Course Structure

1. Introductory concepts

1.1. Introduction

• Brief history and objectives
• Definitions and strategies
• Challenges and Applications

1.2. Applied Molecular and Cellular Biology

• Cells, tissues, organs, systems and organs
• Stem cells
• Tissue repair versus regeneration


1.3. Therapeutic agent release systems

1.4. Bioreactors for Regenerative Medicine and Tissue Engineering


2. Systems and tissues

The lessons of module 2 have a theoretical and practical component, based on analysis, presentation and discussion of selected published works on the subject of the curricular unit.



2.1. Skin Regeneration and plastic and reconstructive surgery

• Repair and regeneration of skin
• Artificial skin
• Plastic surgery

2.2. Cardiovascular system

• Artificial blood
• Heart
• Blood vessels

2.3. Musculoskeletal system

• Regeneration and bone repair
• Periodontal and dental applications
• Cartilage
• Artificial ligaments and tendons
• Muscle

2.4. Nervous system

• Peripheral nervous system (PNS)
• Central nervous system (CNS)
- Spinal cord
- Brain
- Retina

2.5. Construction of organs

• Digestive System
• Endocrine and urinary systems


3. Social, economical, ethical and regulatory issues

Mandatory literature

ed. Clemens van Blitterswijk; Tissue engineering. ISBN: 978-0-12-370869-4

Complementary Bibliography

ed. Anthony Atala [et al.]; Foundations of regenerative medicine. ISBN: 978-0-12-375085-3
ed. Robert Lanza, Robert Langer, Joseph Vacanti; Principles of tissue engineering. ISBN: 978-0-12-370615-7
Edited by Buddy D. Ratner... [et al.]; Biomaterials science. ISBN: 0-12-582463-7
Frontiers in Tissue Engineering, Patrick CW Jr, Mikos AG e McIntire LV, 1998

keywords

Technological sciences > Engineering > Biomaterial engineering
Health sciences > Medical sciences > Medicine
Health sciences > Ethics in health sciences
Technological sciences > Engineering > Biomedical enginnering

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	39,00
	Total:	-	0,00