Biomaterials

Code:

EBE0118

Acronym:

BIOM

Keywords
Classification	Keyword
OFICIAL	Biomedical Engineering

Instance: 2011/2012 - 2S

Active?	Yes
Responsible unit:	Department of Metallurgical and Materials Engineering
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MEB	9	Syllabus	1	-	6	56	162
MIB	22	Syllabus	3	-	6	56	162
PRODEB	7	Syllabus	1	-	6	56	162

Teaching language

English

Objectives

To provide fundamental principles on Biomaterials Science and Engineering and state of the art knowledge on biomaterials development, in particular for the most relevant medical applications. Since the interaction between biomaterials and tissues is a critical aspect in the performance of biomaterials, the course will cover several of its facets, including the dialogue with the microenvironment and its cellular and extracellular components. The new generation biomaterials designed at the molecular level, using nanotechnology approaches, will be also covered in depth. Their application in regenerative medicine will also be highlighted.

Program

1. Fundamentals of Biomaterials
Evolution of biomaterials and implantable medical devices
Degradable and non-degradable biomaterials
Clinical applications and complications

2. Biomaterials in the biological microenvironment
The host tissue response
Interactions with proteins, cells and the extracellular matrix
Biomaterials degradation: mechanisms; the pros and cons of degradation

3. Modulation of the biological response
Surface modifications
Natural and engineered biomimetic self-assembled constructs
Nanobiotechnology applied to the design of novel biomaterials

4. Fundamentals of tissue regeneration
Objectives and strategies
Cells, molecular signs and scaffolds

5. The proof of concept
Medical applications in tissue repair, replacement and regeneration.
Ethical, social, economic and regulatory issues

Mandatory literature

Ratner, Buddy D. 340; Biomaterials science. ISBN: 0-12-582463-7
Dee, Key C.; An Introduction to tissue-biomaterial interactions. ISBN: 0-471-25394-4
Di Silvio, L.; Cellular Response to Biomaterials, Woodhead Publishing in Materials, 2009. ISBN: 978-1420093735
Atala, A.; Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, Academic Press, 2009. ISBN: 978-0123750853

Teaching methods and learning activities

The key aspects of each topic will be presented first by the lecturer. This will be followed by a thorough discussion in subsequent classes and presentation of critical examples by the students, resulting from a literature search. The discussion may be led by one to three students and can be kicked-off by a brief presentation (typically 10 min).

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	48,00
	Total:	-	0,00

Eligibility for exams

The student must have taken a leading role in at least one presentation (see above) and participate in at least 75% of the classes.

Calculation formula of final grade

The final mark will result from the mark obtained in the final exam (50%; minimum “8 valores”), lab sessions (30%) and the mark obtained in the classes (20%: presentations, discussions and answer to questionnaires).
For doctoral students, participation in laboratory classes will be replaced by the writing of a research assay on any subject related to their scientific interests, provided that it fits into the program of the UC.

Examinations or Special Assignments

Not applicable.

Special assessment (TE, DA, ...)

As specified by the rules applicable to the Mestrado Integrado em Bioengenharia.

Classification improvement

As specified by the rules applicable to the Mestrado Integrado em Bioengenharia.