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Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines

Title
Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines
Type
Another Publication in an International Scientific Journal
Year
2002
Authors
Marques, CG
(Author)
Other
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Pedro, M
(Author)
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Simoes, MFA
(Author)
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Nascimento, MSJ
(Author)
FFUP
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Pinto, MMM
(Author)
FFUP
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Rodriguez, B
(Author)
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Journal
Title: Planta MedicaImported from Authenticus Search for Journal Publications
Vol. 68
Pages: 839-840
ISSN: 0032-0943
Publisher: Thieme
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-000-N7T
Abstract (EN): Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gurke, were evaluated for their in vitro anti proliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 2
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