The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Coimbra, S (Author) Other; Catarino, C (Author) Other; Faria, MS (Author) Other; José Pedro Nunes (Author) FMUP; Rocha, S (Author) Other; Valente, MJ (Author) Other; Rocha Pereira, P (Author) Other; Bronze da Rocha, E (Author) FFUP; Bettencourt, N (Author) Other; Beco, A (Author) Other; Marques, SHD (Author) Other; José Oliveira (Author) FMUP; António Madureira (Author) FMUP; Fernandes, JC (Author) Other; Miranda, V (Author) Other; Belo, L (Author) Other; Alice Santos Silva (Author) FFUP

Journal

Title: Biomedicines

Vol. 11

Final page: 1026

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-5DJ

DOI: 10.3390/biomedicines11041026

Abstract (EN): Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (n = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13