p53 family interactions and yeast: together in anticancer therapy

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Gomes, S (Author) Other; Leao, M (Author) Other; Raimundo, L (Author) Other; Ramos, H (Author) Other; Soares, J (Author) Other; Lucilia Saraiva (Author) FFUP

Journal

Title: Drug Discovery Today

Vol. 21

Pages: 616-624

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00N-GG4

DOI: 10.1016/j.drudis.2016.02.007

Abstract (EN): The p53 family proteins are among the most appealing targets for cancer therapy. A deeper understanding of the complex interplay that these proteins establish with murine double minute (MDM)2, MDMX, and mutant p53 could reveal new exciting therapeutic opportunities in cancer treatment. Here, we summarize the most relevant advances in the biology of p53 family protein-protein interactions (PPIs), and the latest pharmacological developments achieved from targeting these interactions. We also highlight the remarkable contributions of yeast-based assays to this research. Collectively, we emphasize promising strategies, based on the inhibition of p53 family PPIs, which have expedited anticancer drug development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9