Go to:
Logótipo
You are here: Start > Project: EXPL/NAN-MAT/0209/2021

Project: EXPL/NAN-MAT/0209/2021

Project name: NanoSAURUS - Nanotech-double functionalized particles to transport Nucleic Acid Mimics against Staphylococcus Aureus
Project code: EXPL/NAN-MAT/0209/2021
Intervention Region: Norte
Proposing institution/Lead promoter/Coordinating entity: Faculdade de Engenharia da Universidade do Porto
Date of approval: 2021-10-15
Start date: 2022-01-16
Completion date: 2024-01-15
Eligible Cost of the Project
Total Eligible Cost: 49.982,18 EUR
Eligible Cost in the University of Porto: 49.982,18 EUR
Faculdade de Engenharia da Universidade do Porto: 49.982,18 EUR
Total Financial Support
Orçamento de Estado: 49.982,18 EUR
Financial Support to the University of Porto
Total of the University of Porto: 49.982,18 EUR
Nacional/Regional | Orçamento de Estado | Faculdade de Engenharia da Universidade do Porto: 49.982,18 EUR
Objectives, activities and expected/achieved results
The main scientific goal of this project is to improve the diffusion of NAMs through the bacterial envelope of S. aureus and consequently be a step closer to the use of NAMs as novel antibacterial nano-based drug. For that, we propose to develop novel nanotech-double functionalized particles to transport the NAMs to promote the decline of S. aureus related diseases. As many technological challenges hamper the development of antibacterial strategies, nanotechnology seems to be a suitable approach to overcome these challenges and allow the development of novel functional therapeutic strategy. Thus, this plan focuses on the use of NAMs encapsulated into PLGA NPs. The encapsulation of these molecules in NPs with a modified surface will allow to increase their specificity and ability to enter in the bacteria. This nanostrategy is deigned to be used by intravenous administration. However, in the future, other routs of administration, such as oral administration, could be a possibility. Additionally, this strategy could be applied for the treatment of other bacterial infections caused from different bacteria, through the use of different NAMs and other phage proteins specific for other bacteria.
The overall objective (O) will be achieved through 4 specific ones:
O.1: To select appropriate NAMs against S. aureus
O.2: To product and in vitro characterization of reproducible PLGA NPs containing NAMs
O.3: To modify the PLGA NPs surface to increase their specificity and uptake in bacteria through the use of phage proteins and CPPs O.4: To evaluate the in vitro efficacy of the nanocarrier to deliver the NAMs into bacteria
Recommend this page Top
Copyright 1996-2025 © Faculdade de Engenharia da Universidade do Porto  I Terms and Conditions  I Accessibility  I Index A-Z  I Guest Book
Page generated on: 2025-12-16 at 23:41:49 | Acceptable Use Policy | Data Protection Policy | Complaint Portal