Hepatobiliary dysfunction and HIV infection [Alterações hepatobiliares e infecção pelo VIH: O caso particular da colangiopatia da sida]

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2002

Autores

Moutinho Ribeiro, P (Autor) Outra; Macedo G (Autor) Outra

Revista

Título: Arquivos de Medicina

Vol. 16

Páginas: 163-167

ISSN: 0871-3413

Editora: A E F M U P, Alameda prof. H. Montiero

Indexação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-007-A9E

Abstract (EN): Summary: Patients infected with the human immunodeficiency virus (HIV) frequently present dysfunction related to hepatobiliary involvement. The more common clinic presentation are the alterations of the laboratorial tests, either reflecting hepatocellular damage (elevation of ALT and AST) or cholestasis (elevation of the alkaline fosfatase and gamma-GT). These can be due to primary or secondary infections of the liver and biliary system, to neoplastic involvement, or to alterations of the hepatic metabolism as a direct or indirect consequence of the HIV infection. AIDS cholangiopathy is a clinical-pathological entity characterized morphologically by alterations in the biliary system of individuals infected with HIV in severe immunosuppression (generally with CD4 lymphocytes countings inferior to 200/mm3), with serious deterioration of general state and with coexistent infection or neoplasia. It occurs approximately in 5% of AIDS patients. The patients usually present with pain in the right upper abdominal quadrant and accentuated elevation of the alkaline fosfatase and, sometimes, fever. Diagnosis should be suspected by the presence of biliary tree dilation in ultrassonography and is supported by characteristic aspects in endoscopic retrograde cholangiopancreatography (ERCP). We review some aspects of this entity regarding the pathogeny, clinical presentation, diagnosis, cholangiographic patterns and treatment.

Idioma: Português

Tipo (Avaliação Docente): Científica