CIRCULATING IMMUNE-COMPLEXES IN BUERGERS-DISEASE - ENDARTERITIS OBLITERANS IN YOUNG MEN

• Tipo: Artigo em Revista Científica Internacional
• Data: 1989

Autores

Roncon Albuquerque R. (Autor) FMUP; Delgado L. (Autor) FMUP; Correia P. (Autor) Outra; Braga A. (Autor) Outra; Serrão D (Autor) Outra; Torrinha F. (Autor) FMUP

Revista

Título: Journal of Cardiovascular Surgery

Vol. 30 Nº 5

Páginas: 821-825

ISSN: 0021-9509

Editora: EDIZIONI MINERVA MEDICA

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 35 Citações

Classificação Científica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Cirurgia

Outras Informações

ID Authenticus: P-001-SEZ

Abstract (EN): Some studies have revealed pecularieties to the immune response in Buerger's syndrome: anti-elastine, anti-collagenic, anti-nucleus and anti-arterial antibodies, circulating immune complexes and celular response to collagens I and III. One of us also found the presence of deposits of IgG, C3 and C4 in vascular lesions (areas of elastic rupture) in the endarteritis obliterans of the young men (Roncon-Albuquerque R, 1983). With the objective of relating the lesions found and clinically revealed vascular disease with the presence of circulating immune complexes (CIC), 33 patients with endarteritis obliterans (E.O.) were studied, 20 with atherosclerosis (A.T.) and 20 normal (N.), all were heavy smokers of the male sex and from the same age group. Five methods of investigation were used. Two nephelometric methods: direct nephelometry (N.D.), nephelometry with protamine (N.P.); two methods of precipitancy with polyethylene glycol (PegIgG and PegC4) and one immuno-enzymatic method of fixation to C1q (C1qE). The results indicate towards the presence of C.I.C. in peripheric arterial disease in the young smoker, particularly in situations of Endarteritis Obliterans of the young men.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5