Resumo (PT):
Bisnaphthalimidopropyl derivatives (BNIPSpd, BNIPDaoct, BNIPDanon, BNIPDadec, BNIPDpta and BNIPDeta)
were synthesised in yields ranging from 50% to 70% and their cytotoxicity against colon cancer cells (Caco-2) and the parasite Leishmania
infantum determined using the MTT assay. Cytotoxicity within Caco-2 cells was manifested with IC50 values between 0.3 and
22 lM. Compounds with the central longer alkyl chains exhibited the highest cytotoxicity. Against L. infantum, IC50 values were
encompassed within a narrower concentration range of 0.47–1.54 lM. In the parasites, the presence of nitrogen in the central chain
and the length of the central alkyl chains did not especially enhance cytotoxicity. This may be due to the way these compoun transported in the cells.
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<a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF8-4M0J4DK-C&_user=2460038&_coverDate=01%2F01%2F2007&_rdoc=56&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235220%232007%23999849998%23637317%23FLA%23display%23Volume)&_cdi=5220&_sort=d&_docanchor=&_ct=62&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=3d43af542c1b7a59b0dd3a4b912f4032"> Texto integral </a>
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Abstract (EN):
Bisnaphthalimidopropyl derivatives (BNIPSpd, BNIPDaoct, BNIPDanon, BNIPDadec, BNIPDpta and BNIPDeta) were synthesised in yields ranging from 50% to 70% and their cytotoxicity against colon cancer cells (Caco-2) and the parasite Leishmania infantum determined using the MTT assay. Cytotoxicity within Caco-2 cells was manifested with IC50 values between 0.3 and 22 mu M. Compounds with the central longer alkyl chains exhibited the highest cytotoxicity. Against L. infantum, IC50 values were encompassed within a narrower concentration range of 0.47-1.54 mu M. In the parasites, the presence of nitrogen in the central chain and the length of the central alkyl chains did not especially enhance cytotoxicity. This may be due to the way these compounds are transported in the cells.
Idioma:
Inglês
Tipo (Avaliação Docente):
Científica
Nº de páginas:
5