Drug combination and repurposing for cancer therapy: the example of breast cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Correia, AS (Autor) Outra; Gartner, F (Autor) Outra; Nuno Vale (Autor) FMUP

Revista

Título: Heliyon

Nº de Série 6 Vol. 7

ISSN: 2405-8440

Editora: Elsevier

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-00T-A79

DOI: 10.1016/j.heliyon.2021.e05948

Abstract (EN): Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it affects and kills millions of people worldwide, being the subject of intense study both in its pathophysiology and therapy.Especially in women, breast cancer is still a cancer with a high incidence and mortality. Even though mortality rates for this type of cancer have declined in recent years, it remains challenging at the treatment level, especially the metastatic type. Due to all the impact on health, cancer therapy is the subject of costly and intense research.To enrich this therapy, as well as decrease its underlying high associated costs, drug repurposing and drug combinations are strategies that have been increasingly studied and addressed. As the name implies, drug repurposing presupposes giving new purposes to agents which, in this case, are approved for the therapy of other diseases (for example, cardiovascular or metabolic diseases), but are not approved for cancer therapy. Therefore, abetter knowledge of these therapeutic modalities for breast cancer therapy is crucial for improved therapy. In this particular review, we will discuss some relevant aspects of cancer and, particularly, breast cancer and its therapy.Also, drug combination and repurposing will be highlighted, together with relevant examples. Despite some limitations that need to be overcome, these methodologies are extremely important and advantageous incombating several current problems of cancer therapy, namely in terms of costs and resistance to current the rapeutic modalities. These approaches will be explored with a special focus on breast cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9