Post grafted gallic acid to chitosan-Ag hybrid nanoparticles via free radical-induced grafting reactions

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Hussein, MAM (Autor) Outra; Olmos, JM (Autor) Outra; Piernski, MK (Autor) Outra; Grinholc, M (Autor) Outra; Buhl, EM (Autor) Outra; Gunduz, O (Autor) Outra; Youssef, AM (Autor) Outra; Carlos M Pereira (Autor) FCUP; El-Sherbiny, IM (Autor) Outra; Megahed, M (Autor) Outra

Revista

Título: International Journal of Biological Macromolecules

Vol. 233

ISSN: 0141-8130

Editora: Elsevier

Indexação

ISI Web of Knowledge - 4 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-WE4

DOI: 10.1016/j.ijbiomac.2023.123395

Abstract (EN): The present study proposes two unique systems using free radical-induced grafting reactions to combine Ag, chitosan (CS) and gallic acid (GA) into a single particulate nanostructure. GA-grafted-CS (GA-g-CS) was used to reduce Ag+ to Ag0, and producing Ag-GA-g-CSNPs (hybrid NPs I). Also, GA was grafted into CS-AgNPs, to form GA-g-CS AgNPs (hybrid NPs II). Although there were previous attempts to graft GA into CS, this is first time to graft GA into CS-AgNPs. The study aimed to enhance biocompatibility, antibacterial and antioxidant properties of CS-AgNPs via grafted GA. Grafting GA into CS-AgNPs was confirmed by UV-Vis, DLS, DSC/TGA, XRD, EDX and FTIR. The morphology and size of NPs were studied by TEM and SEM. The decrease of zeta-potential from +50 mV in CS-Ag NPs to +33 and + 29 mV, in the presented 2 nanoforms hybrid NPs I and II, respectively, is an indication for the successful GA graft. Among all samples, hybrid NPs II showed lower toxicity, higher antiox-idant and antibacterial activity. The obtained results revealed that grafting GA to CS-AgNPs, as a new method to combine Ag, CS and GA in a uniparticulate structure, is a unique process which may deserve a more future consideration.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13