Palladium-catalysed reactions of 8-hydroxy- and 8-benzyloxy-5,7-diiodoquinoline under aminocarbonylation conditions

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Takacs, A (Autor) Outra; Szilagyi, A (Autor) Outra; Acs, P (Autor) Outra; Mark, L (Autor) Outra; Peixoto, AF (Autor) FCUP; Pereira, MM (Autor) Outra; Kollar, L (Autor) Outra

Revista

Título: Tetrahedron

Vol. 67

Páginas: 2402-2406

ISSN: 0040-4020

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-002-SZ5

DOI: 10.1016/j.tet.2011.02.003

Abstract (EN): Various 5-carboxamido-7-iodo-8-benzyloxyquinolines were synthesised via selective aminocarbonylation of 5,7-diiodo-8-benzyloxyquinoline in the presence of in situ generated palladium(0) catalysts. Under similar conditions (50 degrees C. 80 bar CO), 5,7-bis(N-tert-butyl-glyoxylamido)-8-hydroxyquinoline was obtained using tert-butylamine as N-nucleophile. The unprotected 5,7-diiodo-8-hydroxyquinoline underwent dehydroiodination resulting in 8-hydroxyquinoline as the major product.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5