Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Ferreira Duarte, M (Autor) Outra; Sousa, JB (Autor) Outra; Diniz, C (Autor) FFUP; Sousa, T (Autor) FMUP; Duarte Araujo, M (Autor) Outra; Morato, M (Autor) FFUP

Revista

Título: Current Pharmaceutical Design

Vol. 26

Páginas: 3733-3747

ISSN: 1381-6128

Editora: Bentham

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00S-QZD

DOI: 10.2174/1381612826666200701212414

Abstract (EN): The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15