Antiproliferative effect of beer and hop compounds against human colorectal adenocarcinome Caco-2 cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Machado, JC (Autor) Outra; Faria, MA (Autor) Outra; Melo, A (Autor) Outra; Ferreira, Isabel (Autor) FFUP

Revista

Título: Journal of Functional Foods

Vol. 36

Páginas: 255-261

ISSN: 1756-4646

Editora: Elsevier

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00M-ZKY

DOI: 10.1016/j.jff.2017.07.006

Abstract (EN): Xanthohumol, isoxanthohumol, alpha and beta-acids and iso-alpha-acids from hops exhibit beneficial properties with promising effects in cancer therapy, however information regarding their effects on colon Caco-2 cells is missing. Herein these compounds and a beer base matrix were tested for antiproliferative activity in the referred cells. Xanthohumol did not show antiproliferative activity at concentrations from 0.313 to 20 mu g/mL. Isoxanthohumol was able to inhibit proliferation by 25% at 10-20 mu g/mL when pure solution and increase 7-13% the activity of the matrix when spiked. alpha and beta-acids and iso-alpha-acids, presented IC50 values of 16.16 +/- 3.11 and 50.61 +/- 13.08 mu g/mL, respectively. A synergist effect with the beer matrix was noticed for alpha and beta-acids and iso-alpha-acids which increased the activity by 36% and 23% at 80 and 100 mu g/mL, respectively. The antiproliferative effects of the beer matrix components are thus dependent on both brewing process and hops addition.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7