Multifunctional PLLA-ceramic fiber membranes applications for bone regeneration

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Santos, JD (Autor) FEUP; Silva, D.M. (Autor) Outra; Gomes PS (Autor) FMDUP; Fernandes MH (Autor) FMDUP; Santos, J.D. (Autor) Outra; Sencadas, V. (Autor) Outra

Revista

Título: Journal of Colloid and Interface Science

Vol. 504

Páginas: 101-110

ISSN: 0021-9797

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

ISI Web of Science

Scopus - 18 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00M-TJ8

DOI: 10.1016/j.jcis.2017.05.032

Abstract (EN): A novel method to process electrospun poly(L-lactic acid) (PLLA) membranes incorporating glass reinforced hydroxyapatite granules (gHA) interspacially between the polymeric fibers is reported, thus increasing the surface area for cellular interactions. gHA granules (<= 150 mu m) electrospun together with the polymer solution, lead to an average fiber diameter of 550 150 nm for pristine PLLA and 440 170 nm for the composite samples. An increase of the overall porosity was observed, from 79 +/- 3% for the PLLA up to 88 +/- 5% for the hybrid samples, keeping material's wettability and mechanical properties. Bone-bonding ability showed that both samples induced HA crystal nucleation, but with a distinct pattern of mineral deposition. gHA microcomposite allows a better F-actin cytoskeleton organization during the initial adhesion and spreading, favoring cell-fibers and cell-to-cell interactions and enhanced alkaline phosphatase activity, making them potential candidates for bone healing strategies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10