Engineering proteolytically-degradable artificial extracellular matrices

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Keila B Fonseca (Autor) Outra; Pedro L Granja (Autor) FEUP; Cristina C Barrias (Autor) Outra

Revista

Título: Progress in Polymer Science

Vol. 39

Páginas: 2010-2029

ISSN: 0079-6700

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 2 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-009-Z9C

DOI: 10.1016/j.progpolymsci.2014.07.003

Abstract (EN): Hydrogels are widely used as provisional matrices for tissue engineering and regenerative medicine, showing also great promise as platforms for 3D cell culture. Different bio-functionalization strategies have been proposed to enhance the biological performance of hydrogels, particularly when they lack intrinsic bioactivity. In this context, the design of artificial materials that mimic structural and functional features of the natural extracellular matrix (ECM) has been pursued. This review presents an overview on bioengineering approaches of integrating protease-sensitive motifs into hydrogels, for the creation of cell-responsive biomimetic scaffolding materials that degrade in response to their proteolytic microenvironment The successful incorporation of protease-sensitive motifs in several synthetic and natural polymers, which has been achieved using various chemical routes, is described. In each case, the selected peptide sequences and their target proteases are highlighted, along with the main achievements of the study. A critical analysis of current limitations and recent advances is also provided, along with suggestions for further improvements. (C) 2014 Elsevier Ltd. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20