Dysprosody during epileptic seizures lateralizes to the nondominant hemisphere

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Peters, AS (Autor) Outra; Remi, J (Autor) Outra; Vollmar, C (Autor) Outra; Gonzalez Victores, JA (Autor) Outra; Cunha, JPS (Autor) FEUP; Noachtar, S (Autor) Outra

Revista

Título: Neurology

Vol. 77

Páginas: 1482-1486

ISSN: 0028-3878

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-002-KZF

DOI: 10.1212/wnl.0b013e318232abae

Abstract (EN): Objective: In human speech, the changes in intonation, rhythm, or stress reflect emotions or intentions and are called prosody. Dysprosody is the impairment of prosody and has been described in stroke and neurodegenerative disorders. Reports in epilepsy patients are limited to case reports. Methods: We assessed prosody qualitatively and quantitatively in 967 focal epilepsy patients. The qualitative assessment was performed by 2 native German speakers, and the quantitative frequency analysis used linguistic software tools. For the quantitative analysis, the formant F0 (a frequency peak, which is an approximation of pitch) and the further spectral frequency peaks of our patients' voices were analyzed. Results: We found 26 patients with ictal dysprosody through qualitative analysis (2.7% of all focal epilepsies). The qualitative changes affected mostly the pitch and the loss of melody. The seizure patterns at the time of ictal dysprosody were always in the nondominant hemisphere (100%) and were mostly right temporal (n = 22; 84.6%). Quantitative analysis of 15 audio samples (11 patients) showed a change in the frequency of formant F0 of several patients and a reduction of frequency variation during ictal speech, expressed as the SD of formant F0 (ictal 14.1 vs interictal 27.2). Conclusions: Ictal dysprosody localizes seizure onset or propagation to the nondominant temporal lobe. This information can be used in the evaluation of patients considered for resective epilepsy surgery. Neurology (R) 2011; 77: 1482-1486

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5